CD39-L4 Is a Secreted Human Apyrase, Specific for the Hydrolysis of Nucleoside Diphosphates
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چکیده
منابع مشابه
Enzymatic synthesis of nucleoside diphosphates and triphosphates.
It has been recognized from recent studies that nucleoside triphosphates, other than ATP,’ function in biologic systems as phosphorylating agents (1) and in coenzyme synthesis (2) in a manner analogous to that of ATP. The discovery of the natural occurrence of a variety of purine and pyrimidine nucleoside diand triphosphates (3-5) and the likelihood that new biologic functions for these nucleot...
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A procedure for the preparation and isolation of nucleoside-5’-diphosphates
Tris[bis(triphenylphosphoranylidene)ammonium] pyrophosphate (PPN pyrophosphate) was used in the SN2 displacements of the tosylate ion from 5'-tosylnucleosides to afford nucleoside-5'-diphosphates. Selective precipitation permitted the direct isolation of nucleoside-5'-diphosphates from crude reaction mixtures.
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It was found that nucleoside 5'-diphosphates could serve as effectors of ribonucleotide reductase. ADP was an activator of CDP reduction; ADP reduction was activated by dGDP; GDP reduction was activated by dTDP. Conversely, dADP inhibited the reduction of CDP, UDP, GDP, and ADP; dGDP inhibited UDP and GDP reductions; and dTDP inhibited UDP reduction. The inhibition of UDP reduction by dADP, dTD...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1999
ISSN: 0021-9258
DOI: 10.1074/jbc.274.29.20064